Kinase Pathway Targeted Therapeutics

Instructions

  • Read the following information before beginning the educational activity and click the "Continue" link at the bottom of the page.
  • View the educational activity.
  • Complete the CME post-test and evaluation.
  • After successful completion of the CME post-test and evaluation, you will receive the credit or participation certificate

*The CME post-test and evaluation must be completed by April 19, 2022 in order to receive the credit or participation certificate.

Target Audience

Physicians who wish to advance their current knowledge of role of BRAF inhibitors in BRAF V600-mutant cancers.

Learning Objectives

  1. To enumerate the somatic genetic alterations that result in MAP kinase pathway activation and dependence.
  2. To summarize supporting the use of BRAF inhibitor-based therapy for BRAF V600 mutant cancers.
  3. To describe the unique therapeutic strategies currently being investigated in MAP kinase pathway activated tumors outside of BRAF V600 mutations.

Accreditation and Credit Designation

The Society for Translational Oncology is accredited by the ACCME to provide continuing medical education for physicians.

The Society for Translational Oncology designates this CME activity for a maximum of 0.5 AMA PRA Category 1 Credit™. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Disclosure Policy

It is the policy of the Society for Translational Oncology (STO) to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities through the disclosure of financial interests and other relationships.  As an education provider accredited by the Accreditation Council for Continuing Medical Education (ACCME), STO must comply with the ACCME Standards for Integrity and Independence.
 
In accordance with the policy of STO, all persons in a position to control the content of a CME activity must disclose any financial relationships with ineligible companies occurring within the last 24 months. STO abides by a policy of anonymous peer review: disclosure of any financial relationships with ineligible companies/commercial interests will be reviewed by the CME Activity Directors with the ad hoc assistance of external reviewers; any conflicts of interest found will be mitigated prior to the activity.
 

Acknowledgement 

This activity was funded in part through educational grants from Novartis Pharmaceuticals Corp. and Regeneron Pharmaceuticals, Inc and Sanofi Genzyme.

Author Disclosure(s)

Keith Flaherty, M.D.
  • Board of Directors: Clovis Oncology, Strata Oncology*, Checkmate Pharmaceuticals, Kinnate BioPharma
  • Scientific Advisory Board: X4 Pharmaceuticals*, PIC Therapeutics, Apricity*, Tvardi, xCures, Monopteros, Vibliome, ALX Oncology
  • Consultant: Lilly, Novartis, Takeda, Boston Biomedical
*co-founder

Moderator Disclosure

Bruce Chabner, M.D.
EMD Serono, Cyteir, Eli Lilly & Co., Boston Pharmaceuticals, Chugai Pharmaceuticals.

Aditya Bardia, M.D., MPH
Advisory role with Pfizer, Novartis, Genentech, Merck, Radius Health, Immunomedics, Taiho, Sanofi, Diiachi Pharma/Astra Zeneca, Puma Biotechnology, Biothernostics Inc., Phillips, Eli Lilly, Foundation Medicine.
Research funding from BGenentech, Novartis, Pfizer, Merck, Sanofi, Radius Health, Immunomedics, Diiachi Pharma/Astra Zeneca. 

CME Activity Directors Disclosures

Jayne S. Gurtler, M.D., F.A.C.P., CME Program Editor

No financial relationships relevant to the content of this activity have been disclosed.

Staff Planners Disclosures

No financial relationships relevant to the content of this actvity have been disclosed by the staff planners.

Commercial Support

This activity was funded in part through educational grants from Novartis Pharmaceuticals Corp. and Regeneron Pharmaceuticals, Inc and Sanofi Genzyme.

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